A brief history of RNAi: the silence of the genes
- 1 July 2006
- journal article
- review article
- Published by Wiley in The FASEB Journal
- Vol. 20 (9) , 1293-1299
- https://doi.org/10.1096/fj.06-6014rev
Abstract
The use of the RNA interference (RNAi) pathway to eliminate gene products has greatly facilitated the understanding of gene function. Behind this remarkable pathway is an intricate network of proteins that ensures the degradation of the target mRNA. In this review, we explore the history of RNAi as well as highlighting recent discoveries.Keywords
Funding Information
- Howard Hughes Medical Institute
- National Institutes of Health (HD018179, AG009521, AG024987, AG020961)
- Ellison Medical Foundation (AGSS-0817-03)
- Baxter International Foundation
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