GABA agonists in cebus monkeys with neuroleptic-induced persistent dyskinesias
- 1 March 1988
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 94 (3) , 298-301
- https://doi.org/10.1007/bf00174678
Abstract
Tetrahydroisoxazolopyridinol (THIP), a GABA receptor agonist, γ-acetylenic-GABA(GAG) and γ-vinyl-GABA(GVG), two GABA transaminase inhibitors were given in single parenteral doses to three Cebus apella monkeys with persistent dyskinetic movements induced by earlier long-term administration of haloperidol. High doses of THIP temporarily abolished dyskinesias but also caused bradykinesia, ataxia, dystonia and myoclonic jerks. GAG and GVG reduced dyskinesias to a lesser extent and with fewer side effects. Whether the observed antidyskinetic effect is secondary to the concomitant general toxic effects or if these drugs have a specific antidyskinetic action remains an open question.Keywords
This publication has 27 references indexed in Scilit:
- Gamma-vinyl-GABA treatment of tardive dyskinesia and other movement disordersBiological Psychiatry, 1985
- Effects of Sulpiride on Persistent Neuroleptic-induced Dyskinesia in MonkeysActa Psychiatrica Scandinavica, 1984
- GABA AGONIST TREATMENT IMPROVES TARDIVE DYSKINESIAThe Lancet, 1983
- Increased gamma-aminobutyric acid (GABA), homocarnosine and β-alanine in cerebrospinal fluid of patients treated with γ-vinyl GABA (4-amino-hex-5-enoic acid)Life Sciences, 1981
- EFFECT OF DRUGS ON RAT BRAIN, CEREBROSPINAL FLUID AND BLOOD GABA CONTENTJournal of Neurochemistry, 1979
- The relationship between GABA concentrations in brain and cerebrospinal fluidBrain Research, 1979
- GABA in plasma and cerebrospinal fluid of different species. Effects of γ‐acetylenic GABA, γ‐vinyl GABA and sodium valproateJournal of Neurochemistry, 1979
- γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE1Journal of Neurochemistry, 1977
- THE EFFECT OF 4‐AMINO HEX‐5‐YNOIC ACID (γ‐ACETYLENIC GABA, γ‐ETHYNYL GABA) A CATALYTIC INHIBITOR OF GABA TRANSAMINASE, ON BRAIN GABA METABOLISM IN VIVOJournal of Neurochemistry, 1977
- The use of autoradiographic techniques for the identification and mapping of transmitter-specific neurones in the brainLife Sciences, 1974