Plasma-Volume Determinations in Rheumatic Subjects during Oral Salicylate Therapy

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Abstract
COBURN'S1 report advocating large doses of salicylates in rheumatic fever aroused widespread interest in the problem of salicylate intoxication. The milder symptoms of nausea, vomiting, tinnitus, deafness and vertigo are considered to be of minor significance. The origin of these symptoms and the action of sodium bicarbonate in alleviating them have been discussed by Smull and her associates2 and Caravati and Cosgrove.3 The more serious toxic complications, including death, delirium, dyspnea, acidosis, hypoprothrombinemia and hemorrhage have been investigated by Ryder et al.,4 Manchester,5 Owen and Bradford6 and Jager and Alway.7 The last investigators suggested the possibility of an increased plasma . . .