A computer program for molecular weight determination of DNA fragments (HOWBIG)
- 1 July 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 7 (3) , 317-319
- https://doi.org/10.1093/bioinformatics/7.3.317
Abstract
The computer program HOWBIG has been developed based on the reciprocal correlation of size to migration distance of DNA in high voltage gradient gel systems (Southern, 1979). For calculation the program automatically chooses three marker bands migrating closest to the calculated band, reducing the error down to ∼0.5% or less (reciprocal method, local form of calculation). The big advantages of the completely menu-driven program are high accuracy, error detectability, speed and ease of data handling. Management of marker-DNA molecular weights, data and analyses as files included in the menu driven program speeds up every-day lab work.Keywords
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