Endothelial lipase colon; a new member of the triglyceride lipase gene family
- 1 April 2000
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Lipidology
- Vol. 11 (2) , 141-147
- https://doi.org/10.1097/00041433-200004000-00006
Abstract
The triglyceride lipase gene family plays a central role in intestinal lipid absorption, energy homeostasis, lipoprotein metabolism, and atherosclerosis. A new member of this gene family, termed endothelial lipase, was recently reported. The presence of key functional motifs, the endothelial synthesis, the enzymatic profile, and the in-vivo metabolic effects of endothelial lipase suggest that, like other members of this gene family, endothelial lipase may play a role in energy delivery to tissues and in modulating lipoprotein metabolism, and could impact on atherogenesis.Keywords
This publication has 38 references indexed in Scilit:
- Cloning of a Unique Lipase from Endothelial Cells Extends the Lipase Gene FamilyJournal of Biological Chemistry, 1999
- A novel endothelial-derived lipase that modulates HDL metabolismNature Genetics, 1999
- An Alternative Splicing Form of Phosphatidylserine-specific Phospholipase A1 That Exhibits Lysophosphatidylserine-specific Lysophospholipase Activity in HumansJournal of Biological Chemistry, 1999
- Oligomeric structure of hepatic lipase: evidence from a novel epitope tag techniqueBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1998
- nmd, a novel gene differentially expressed in human melanoma cell lines, encodes a new atypical member of the enzyme family of lipasesFEBS Letters, 1997
- Serine Phospholipid-specific Phospholipase A That Is Secreted from Activated PlateletsJournal of Biological Chemistry, 1997
- Direct Binding of the Proline-rich Region of Protein Tyrosine Phosphatase 1B to the Src Homology 3 Domain of p130CasPublished by Elsevier ,1996
- Molecular pathobiology of the human lipoprotein lipase genePharmacology & Therapeutics, 1996
- Structure of the pancreatic lipase–procolipase complexNature, 1992
- Organization of the human lipoprotein lipase gene and evolution of the lipase gene family.Proceedings of the National Academy of Sciences, 1989