Granulocyte Function in Untreated Acute and Chronic Granulocytic Leukemia

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Abstract
Untreated patients with acute granulocytic leukemia showed impairment of microbicidal activity and, in one, this was associated with myeloperoxidase deficiency and staphylococcal [Staphylococcus aureus] infection. In chronic granulocytic leukemia, there was no significant impairment of microbial killing. Reduction in the capacity to reduce nitro-blue tetrazolium indicated some disturbance of neutrophil function in this disorder.