MORPHOLOGIC AND BIOCHEMICAL-CHANGES IN CARTILAGE OF FOALS TREATED WITH DEXAMETHASONE

  • 1 January 1983
    • journal article
    • research article
    • Vol. 73  (2) , 170-192
Abstract
Epiphyseal and articular cartilages were examined in pony foals treated with i.m. injections of either 0.5 mg dexamethasone/100 kg body wt daily for 3, 8 or 11 mo., or 5.0 mg/100 kg for 11 mo., and in horse foals treated with 5.0 mg/100 kg for 20 wk. The proximal femoral growth plates exhibited increased spatial separation between chondrocyte columns, narrowed zones of disorganized columnar and hypertrophic cartilage, abnormal penetration of hypertrophic cartilage by metaphyseal capillaries, retained cartilage in the spongiosa, distal terminal plate formation, transverse trabeculation, chondronecrosis and metaphyseal osteochondrosis dissecans.

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