STI571 (Imatinib Mesylate) Reduces Bone Marrow Cellularity and Normalizes Morphologic Features Irrespective of Cytogenetic Response
Open Access
- 1 March 2002
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 117 (3) , 360-367
- https://doi.org/10.1309/nr81-vcu0-ckw1-4ht9
Abstract
The tyrosine kinase inhibitor STI571 (imatinib mesylate, Gleevec) is an effective treatment for chronic myeloid leukemia (CML). We examined bone marrKeywords
This publication has 18 references indexed in Scilit:
- Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia ChromosomeNew England Journal of Medicine, 2001
- Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine KinaseScience, 2000
- Normal and chronic phase CML hematopoietic cells repopulate NOD/SCID bone marrow with different kinetics and cell lineage representationThe Hematology Journal, 2000
- The tyrosine kinase inhibitor STI571, like interferon-α, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemiaExperimental Hematology, 2000
- Effects of interferon and hydroxyurea on bone marrow fibrosis in chronic myelogenous leukaemia: a comparative retrospective multicentre histological and clinical studyBritish Journal of Haematology, 2000
- Interferon-α and Bcr-Abl Antisense Oligodeoxynucleotides in Combination Enhance the Antileukemic Effect and the Adherence of CML Progenitors to Preformed StromaLeukemia & Lymphoma, 1999
- Inhibition of the ABL Kinase Activity Blocks the Proliferation of BCR/ABL+Leukemic Cells and Induces ApoptosisBlood Cells, Molecules, and Diseases, 1997
- Apoptosis and proliferation (PCNA labelling) in CML—a comparative immunohistological study on bone marrow biopsies following interferon and busulfan therapyThe Journal of Pathology, 1997
- Increased growth and collagen synthesis of bone marrow fibroblasts from patients with chronic myelocytic leukaemiaBritish Journal of Haematology, 1985
- Quantitation of Bone Marrow Reticulin—A Normal RangeAmerican Journal of Clinical Pathology, 1971