Abstract
(1) The feeding of a phosphorus-deficient diet to mice starting two days after injection of 90Sr, significantly reduced bone-tumour frequency and increased survival-time. (2) Evaluation of the relation of total radiation dose and of dose-rate to tumour frequency suggests that dose-rate is not the major determinant of bone-tumour incidence. The interpretation is compatible with an indirect carcinogenesis by radiation through primary tissue damage. (3) No conclusions can be drawn about the practical applicability of this treatment to accidental 90Sr intoxication in man.

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