Pyrimidine deoxyribonucleotide metabolism in Acholeplasma laidlawii B-PG9

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Abstract
Extracts of A. laidlawii B-PG9 were examined for the enzymes associated with the interconversion of the pyrimidine deoxyribonucleotides and the biosynthesis of thymidine nucleotides. A. laidlawii B-PG9 possessed deaminases for deoxycytidine and dCMP, pyrophosphatases for dUTP, phosphorylases for thymidine and uridine, and a membrane-associated pyrimidines deoxyribonucleoside monophosphate phosphatase activity. The role these enzyme activities have in the generation of deoxyribose 1-phosphate during growth may explain the ability of A. laidlawii B-PG9 to utilize either thymine or thymidine for biosynthesis.