A patient with infantile spasms and low homovanillic acid levels in cerebrospinal fluid: l-dopa dependent seizures?

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Abstract
We report a 3-month-old female with infantile spasms that responded transiently to pyridoxine and permanently to oral l-dopa. Initial CSF levels of homovanillic acid were low, suggesting disturbed turnover of dopamine. These findings suggest that disturbed brain monoamine metabolism may be causally related to infantile spasms.