Decrease in effects of muscimol on the dorsal root after repeated administration of diazepam in rats.
- 1 January 1981
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 4 (12) , 947-951
- https://doi.org/10.1248/bpb1978.4.947
Abstract
In in situ experiments on spinal rats transected at the C1 level and on non-spinal rats, muscimol (3 mg/kg, i.v.) depolarized the primary afferent fibers; diazepam (3 mg/kg, i.v.) potentiated this effect. When diazepam was given for 14 days, the effect of muscimol was significantly reduced in non-spinal, but not in spinal rats. Diazepam probably interacts with GABA-ergic mechanisms more closely in supraspinal regions of the rat.This publication has 10 references indexed in Scilit:
- Solubilization of benzodiazepine binding site from rat cortexLife Sciences, 1979
- Characteristics of muscimol accumulation in mouse brain after systemic administrationNeuropharmacology, 1979
- Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid.Proceedings of the National Academy of Sciences, 1979
- Distribution and metabolism of muscimol in the brain and other tissues of the ratNeuropharmacology, 1979
- Competitive inhibition of benzodiazepine binding by fractions from porcine brain.Proceedings of the National Academy of Sciences, 1978
- Identification of inosine and hypoxanthine as endogenous inhibitors of [3H] diazepam binding in the central nervous systemLife Sciences, 1978
- Additional studies on the importance of glycine and GABA in mediating the actions of benzodiazepinesLife Sciences, 1977
- Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortexProceedings of the National Academy of Sciences, 1977
- SITE OF ACTION OF THIAMYLAL SODIUM ON THE MONOSYNAPTIC SPINAL REFLEX PATHWAY IN CATSJournal of Neurophysiology, 1964
- Excitability changes in afferent fibre terminations and their relation to slow potentialsThe Journal of Physiology, 1958