Mitochondrial-membrane polar-head-group composition is influenced by diet fat

Abstract
Male Sprague-Dawley rats were fed diets containing 20% (wt/wt) soybean oil, high-erucic acid rapeseed oil or low-erucic acid rapeseed oil for 0, 12 or 23 days. The type of fat present in the diet had no effect on the total phospholipid content of heart mitochondria (.mu.g/mg of protein) but did influence the phospholipid class distribution. Rats fed high erucic acid rapeseed oil for 12 or 23 days had significantly higher mitochondrial phosphatidylcholine content than rats fed soybean oil. Low erucic acid rapeseed oil resulted in elevation of cardiac mitochondrial cardiolipin content after dietary treatment for 12 days. Diet is a significant determinant of the phospholipid class content of subcellular membranes.

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