Ultrastructure of atrophic muscle in amyotrophic lateral sclerosis

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Abstract
The proposed sequence of morphological changes developing in skeletal muscular atrophy In patients with amyotrophic lateral sclerosis can be summarized as follows . myofilamentous disorganization and dissolution, subsarcolemmal mitochondrial hyper-plasia and interfllamentous mitochondrial hypertrophy, fragmentation of Z lines, decrease In fiber size and characteristic sawtoothing of the sarcolemma, mitochondrial Involution In the late stages of the atrophic process coinciding presumably with a decreased metabolic activity of the muscle and no apparent increased lysosomal activity or phagocytosis.