Biological fate of sirdalud in animals and man
- 1 January 1989
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 19 (11) , 1255-1265
- https://doi.org/10.3109/00498258909043177
Abstract
1. Biotransformation and excretion of the muscle relaxant drug, sirdalud, were studied after oral doses of 14C- and 3H-sirdalud in rats, dogs, rabbits, mice and humans. Sirdalud was well absorbed and almost completely metabolized in the five species. 2. Excretion of metabolites was rapid and complete within a few days; the urine/faeces excretion ratio of the 14C label was about 70/30 in all species. Major metabolic pathways of sirdalud were oxidative degradation of the imidazoline ring and oxidation of the aromatic system. 3. A novel oxidative biotransformation pathway of the benzothiadiazole ring system of sirdalud gave a sulphone analogue of the parent drug.This publication has 1 reference indexed in Scilit:
- Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compoundsCellular and Molecular Life Sciences, 1972