Serum Enzyme Changes During Modified Cardiac Rejection in Dogs

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Abstract
The serum activities of glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, ornithine carbamoyl transferase, creatine phosphokinase, alkaline phosphatases, alpha-hydroxybutyric dehydrogenase and lactate dehydrogenase isoenzymes were determined during the rejection of heterotopic cardiac allografts in dogs. A typical release of myocardial enzymes only occurred terminally when electrocardiographic rejection changes had persisted for several days.