Differential effect of cyclo-oxygenase inhibition on antigen- and ionophore-induced release of slow reacting substance from fragmented guinea-pig lung

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Abstract
The nonsteroidal antiinflammatory drugs (NSAID) indomethacin and mefenamic acid, at concentrations ranging from 3 .mu.M-18 .mu.M, enhanced antigen-induced slow reacting substance of anaphylaxis (SRS-A) release from sensitized fragmented guinea-pig lung. These agents had no effect on SRS-A release from nonsensitized guinea-pig lung induced by several concentrations of the Ca ionophore, A23187 [calcimycin]. Neither increasing preincubation time with the NSAID nor the use of sensitized tissue resulted in an enhancement of A23187-induced SRS-A release by indomethacin. NSAID did not alter histamine release by either stimulus. Antigen and A23187 apparently induce SRS-A release from different sources or by different mechanisms in guinea-pig lung.