EFFECT OF 17α-METHYL-β-NORTESTOSTERONE (SK & F 7690) ON THE BINDING IN VITRO OF 5α-DIHYDROTESTOSTERONE TO MACROMOLECULAR COMPONENTS FROM THE RAT VENTRAL PROSTATE
- 1 February 1971
- journal article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 66 (2) , 352-356
- https://doi.org/10.1530/acta.0.0660352
Abstract
Slices from prostate glands of castrated male rats were incubated with [3H] 5α-dihydrotestosterone in Eagle's tissue culture medium. The labelled androgen was associated with androphilic macromolecules both in the prostatic cytosol and the nuclei. The addition of the anti-androgenic compound, 17α-methyl-β-nortestosterone (SK & F 7690) to the incubation medium inhibited the formation of the nuclear 5α-dihydrotestosterone-protein complex, and markedly reduced the cytosol 5α-dihydrotestosterone-protein complex. Likewise, the uptake of [3H] 5α-dihydrotestosterone by the prostatic nuclear fraction was reduced by about 40%.Keywords
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