MICROINJECTION OF KAINIC ACID INTO THE ROSTRAL VENTROLATERAL MEDULLA CAUSES HYPERTENSION AND RELEASE OF NEUROPEPTIDE Y‐LIKE IMMUNOREACTIVITY FROM RABBIT SPINAL CORD
- 1 February 1987
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 14 (2) , 127-132
- https://doi.org/10.1111/j.1440-1681.1987.tb00966.x
Abstract
Microinjections of kainic acid were made into the pressor area of the rostral ventrolateral medulla oblongata of anaesthetized rabbits, in the region of the C1 adrenaline-containing neurons. Over the 65 min following the microinjection, there was a significant increase in blood pressure, as well as an increase in the release of neuropeptide Y-like immunoreactivity into the spinal subarachnoid space. These data provide evidence for a functional bulbospinal neuropeptide Y-containing projection which may be responsible for mediating the pressor effects of stimulation of the rostral ventrolateral medulla.Keywords
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