MAINTENANCE AND RESTORATION OF GROWTH IN THYROIDECTOMIZED RATS

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Abstract
The function of the thyroid glands in regulating the process of body growth was recognized many years ago from observations on human cretins. Subsequently, it was established that thyroidectomy in experimental animals checks the rate of growth, the retardation being greater when the operation is performed very early in life. Though these facts had long been established on a qualitative basis evidence of sufficiently quantitative precision is best available from studies of more recent years. Thus, Salmon [1938] found that the maximal body weight attained by rats thyroidectomized at birth was only 25–35 g. The rate of growth in thyroidectomized animals can be maintained or restored to normal by the administration of various thyroid preparations, such as thyroid gland substance [Smith, Greenwood & Foster, 1927; Salmon, 1938], thyroxine [Evans, Simpson & Pencharz, 1939] or artificial thyroprotein prepared by iodination of the proteins of skimmed milk [Reineke & Turner, 1941]. According

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