STORED-BLOOD PLATELETS AND MICROAGGREGATE FORMATION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 147  (4) , 507-512
Abstract
The structure and function of [human] platelets in stored blood were tested for 21 days of storage with light microscopy and EM as well as determination of platelet aggregation response to AD. Observations were made for a period of 21 days of storage at 4.degree. C. The aqpearance of spontaneous platelet aggregates in stored blood which differed morphologically from aggregates induced by the addition of ADP were demonstrated during the first 10 days of storage. The appearance of spontaneous platelet aggregates paralleled a decrease in platelet count and a progressive decline in the number of morphologically normal appearing platelets. The platelets that were induced to aggregate with AD formed more closely packed aggregates than those that formed spontaneously, and the AD-induced aggregates could still be induced through the 10th day of storage, at which time few morphologically normal platelets could be clearly identified in the plasma. Spontaneous platelet aggregates showed no fibrin in the microaggregates but rather significant numbers of leukocytes contained in the aggregates which degenerated progressively beyond a storage period of 5 days.

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