Effect of Various Steroids on the Hepatic Glucuronidation and Biliary Excretion of Bilirubin
- 1 May 1973
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 51 (5) , 319-323
- https://doi.org/10.1139/y73-048
Abstract
In rats, treatment with spironolactone or pregnenolone-16α-carbonitrile (PCN) accelerates bile flow and enhances hepatic microsomal bilirubin–UDP glucuronyltransferase activity (EC 2.4.1.17) and the biliary transport maximum (Tm) of bilirubin. The distribution of ethylanthranilate azo-pigments in fractions separated by thin-layer chromatography also indicates increased glucuronidation of bilirubin. These findings explain the mechanism of enhanced serum bilirubin disappearance in rats treated with the steroids.Keywords
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