OXYGEN-STABLE HEMOLYSINS OF GROUP A STREPTOCOCCI

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Abstract
The O2-stable streptococcal hemolysins which can be induced by a number of substances differ in electrophoresis, chromatography, pH stability and susceptibility to some organic solvents and to ribonculease. These properties characterize the inducing substances. It is possible to incubate 1 inducer with the hemolysin induced by another of these agents and then, after appropriate fractionation, to find hemolytic activity in the fraction containing the fresh inducer. After transfer of the hemolytic moiety from a hemolysin molecule which is susceptible to inactivation by a given agent or set of conditions to a carrier which is not itself affected by the agent, the new hemolysin is not inactivated by the agent. The hemolysins of this group can be inactivated by enzymatic attack on the prosthetic group, or by hydrolysis or deformation of the postulated carrier molecule.