NEW LOOK AT PLASMA DISAPPEARANCE OF SULFOBROMOPHTHALEIN (BSP) - CORRELATION WITH BSP TRANSPORT MAXIMUM AND HEPATIC PLASMA-FLOW IN MAN

Google Scholar
  • 1 January 1976
    • journal article
    • research article
    • Vol. 88  (6) , 1019-1031
Abstract
To improve the clinical usefulness of the plasma disappearance curve of sulfobromophthalein (BSP), its components were analyzed in 26 control subjects, 28 patients with cirrhosis and 13 cases of miscellaneous liver abnormalities. The uncorrected initial disappearance rate (ki) discriminated best between the control and the patient groups. The 2nd exponential component (k2) was linearly correlated with the transport maximum (Tm) on a double logarithmic plot, but appeared to be independent of the estimated hepatic plasma flow (EHPF). An interpretation of this relationship was possible, when based on a model having saturation kinetics for biliary excretion. The 1st exponential component (ki) appeared primarily determined by hepatic perfusion. These relationships may contribute to a better understanding and more rational use of dye excretion tests as measures of hepatic function. The data also added to the knowledge about the nature of the excretory defect in cirrhosis.