Effect of 1,1-Dimethyl-4-Phenylpiperazinium Iodide on Peristaltic Reflexes of Isolated Guinea Pig Ileum

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Abstract
Summary DMPP has been shown, like nicotine, to augment the peristaltic reflex of an isolated ileum to increasing pressure at low concentrations but inhibits it at high concentrations. This is apparently due to its stimulating and paralyzing action on the parasympathetic ganglion at low and high concentrations, respectively. The fact that the paralyzing effect of DMPP on the ganglia was not evident on repeated administrations in animals of submaximal doses may be explained by the rapid elimination of it from the site of action. Whereas physostigmine antagonized the blocking effect of d-tubocurarine, it does not influence that of DMPP on peristaltic reflexes of the ileum.