AUTORADIOGRAPHIC STUDY ON THE DISTRIBUTION OF (NI-63)-CL-2 IN MICE

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 9  (1) , 47-59
Abstract
The distribution of 63NiCl2 in mice was studied by autoradiography. In the kidney, 63Ni(II) was present at all the survival intervals (5 min to 3 wk) in areas of the cortex, probably corresponding to the distal convoluted tubuli. In the lung, radioactivity occurred in the parenchyma shortly after the administration of 63Ni(II) and was retained throughout the 3 wk observation period. In the brain and spinal cord, a retention of radioactivity was obvious 10 days and 3 wk after administration of 63NiCl2. In cartilage, a high level of 63Ni(II) was present up to 24 h, while in connective tissues there was a high initial radioactivity, followed by a constant decrease during the 7 h after the administration of 63NiCl2. An uptake of 63Ni(II) in cartilage and skin was seen when tissue sections of non-treated mice were incubated in solutions containing 63NiCl2. The chondroitin sulfate of cartilage and the keratin of skin have cation-binding properties which may explain the binding of 63Ni(II) in these tissues.