Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesisElectronic supplementary information (ESI) available: experimental details for the synthesis of 14 and 32. See http://www.rsc.org/suppdata/cc/b2/b209941a/
- 30 October 2002
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 23,p. 2759-2761
- https://doi.org/10.1039/b209941a
Abstract
A total synthesis of Epothilone 490 and a synthesis of 11-hydroxy dEpoB utilizing a vinyl-boronate cross-metathesis followed by a Suzuki macrocyclization. A mild route to reach aldehydes from terminal olefins, anticipating Nozaki–Kishi macrocyclization is described.Keywords
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