Synthesis of Isoflavones from 2′-Hydroxychalcones Using Poly[4-(diacetoxy)iodo]styrene or Related Hypervalent Iodine Reagent
- 20 November 2002
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 2002 (17) , 2490-2496
- https://doi.org/10.1055/s-2002-35617
Abstract
Isoflavones are synthesized in an one-pot reaction by treating the hypervalent iodine(III) reagent, [hydroxy(tosyloxy)iodo]benzene (HTIB, Koser’s reagent) with 2′-benzoyloxychalcones in MeOH. A combined use of (diacetoxyiodo)benzene (DIB)/p-toluenesulfonic acid (TsOH) is also effective for the same purpose. As an extension of these monomeric reagents, polymer-supported DIB {PSDIB, poly[4-(diacetoxy)iodo]styrene} with TsOH works also well. The merits of the latter are the ease of separation of isoflavones from the reaction mixture, no liberation of PhI, and reuse of the reagent.Keywords
This publication has 0 references indexed in Scilit: