In search of anti-Trypanosoma cruzi drugs: new leads from a mouse model
- 1 June 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (6) , 741-744
- https://doi.org/10.1021/jm00216a001
Abstract
Nine of 25 carefully selected compounds (from a stock of more than 200,000 chemical species amassed principally as a result of testing against other parasitic disease) had significant suppressive activity against the parasites in the blood of a T. cruzi mouse model. Eight of these compounds evaluated in this model had suppressive activity equal to or greater than the reference compound, nifurtimox. For the first time, suppressive activity against T. cruzi is reported for a 7-aminoquinoline, a phosphonium salt and TAC [Tris(4-aminophenyl-carbonium)] pamoate. The biological model is believed to be able to serve as a means of identifying other new leads in seeking drugs broadly effective against T. cruzi infections in man.This publication has 2 references indexed in Scilit:
- Screening Large Numbers of Compounds in a Model Based on Mortality of Trypanosoma Rhodesiense Infected Mice *The American Journal of Tropical Medicine and Hygiene, 1976
- Novel Broad-Spectrum Anthelmintics. Tetramisole1 and Related Derivatives of 6-Arylimidazo[2,1-b]thiazoleJournal of Medicinal Chemistry, 1966