Inhibitory activity of pyridindolol on .BETA.-galactosidase.
- 1 January 1976
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (7) , 696-703
- https://doi.org/10.7164/antibiotics.29.696
Abstract
The activity of pyridindolol in inhibiting .beta.-galactosidases obtained from various sources was studied. Whereas acid bovine liver .beta.-galactosidase (optimal pH 4.0) was not affected by this compound, neutral bovine liver .beta.-galactosidase (pH-optimum = 7.0) was inhibited by pyridindolol in reaction mixtures of pH 4.0-5.0. There was no inhibition at pH 7.0. The type of inhibition is non-competitive by formation of a pyridindolol-enzyme complex. Since .beta.-galactosidases from other sources are not affected by pyridindolol, the inhibitory action of this compound seems to be rather specific for neutral bovine liver .beta.-galactosidase.This publication has 6 references indexed in Scilit:
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