The Secretory Immunologic System of Fowl

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Abstract
Pilocarpine-induced oral secretions from normal chickens contained IgA, IgY, and usually some IgM. IgA was usually the predominant immunoglobulin. Approximately 50% of neonatally bursectomized birds lacked IgA in this secretion, and these birds did not compensate with increased IgY or IgM secretion. Chicks receiving anti-μ or Ε(ab′)2 anti-μ prior to hatch and which were bursectomized at hatch had a total lack of secretory IgA in the oral secretions. These results demonstrate the B-cell dependence of secretory IgA synthesis in the chicken and furthermore support the contention that cells supplying IgA to the secretions are derived from IgM-forming precursor cells.

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