Effect of Adrenal Insufficiency on Water and Electrolyte Distribution in the Brain
- 1 July 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Neuropathology and Experimental Neurology
- Vol. 32 (3) , 394-407
- https://doi.org/10.1097/00005072-197307000-00005
Abstract
Three approaches were used in an investigation of the brain edema induced by adrenalectomy. The water, Na+ and K+ content of the brain was determined in mice. The electrical conductivity of rat brain tissue was measured and electron micrographs were prepared from mouse cerebellar cortex fixed by freeze-substitution. The adrenal insufficiency was proven in all animals by means of a water retention test. The results suggested an uptake of water, Na+ and K+ by the extra- and intracellular compartments, in about the same proportion as seen in normal control tissue.Keywords
This publication has 0 references indexed in Scilit: