Reverse Tri-Iodothyronine and Fetal Thyroid Status

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Abstract
During the past 10 years thyroid hormone measurement methods, and thus approaches to thyroid physiology and disease, have changed dramatically. This change has been due largely to the development of radioimmunoassay (RIA) systems specific for pituitary thyrotropin (TSH), the thyroid hormones thyroxine (T4) and 3,3′,5-tri-iodothyronine (T3), the thyroid hormone precursors monoiodotyrosine and diiodotyrosine (MIT and DIT), and the serum thyroid hormone carrier protein of major importance, thyroxine-binding globulin (TBG). In addition, hypothalamic thyrotropin-releasing hormone (TRH) has been isolated and synthesized, and several RIA systems are now available for its measurement in biologic fluids.The most recent . . .