Pulmonary Disposition of Cortisol
- 1 July 1982
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 97 (1) , 59-60
- https://doi.org/10.7326/0003-4819-97-1-59
Abstract
High-dose corticosteroid therapy is used in various lung diseases, yet it is not known if the drug enters the alveolar acinus. Cortisol levels, expressed as a function of albumin concentration, were measured in serum and bronchoalveolar lavage fluid in 12 patients with lung disease. There was a linear relation of cortisol concentration between blood level and bronchoalveolar lavage fluid level when expressed in relation to the albumin concentration (r = 0.93, P < 0.001). Incremental doses of i.v. hydrocortisone reach alveolar structures in a concentration directly related to the circulating blood levels.Keywords
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