Respective roles of short- and long-range interactions in protein folding.
- 1 February 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (2) , 559-563
- https://doi.org/10.1073/pnas.75.2.559
Abstract
A lattice model of protein was studied by a Monte Carlo simulation method. The native conformation of the lattice protein molecule was stabilized by specific long-range and short-range interactions. By comparing results of simulation for different relative weights of the long- and short-range interactions, the specific long-range interactions are essential for highly cooperative stabilization of the native conformation, and the short-range interactions accelerate the folding and unfolding transitions.Keywords
This publication has 3 references indexed in Scilit:
- Studies on protein folding, unfolding and fluctuations by computer simulation. I. The effect of specific amino acid sequence represented by specific inter-unit interactions.1975
- The formation and stabilization of protein structureBiochemical Journal, 1972
- The influence of long-range interactions on the structure of myoglobinBiochemistry, 1968