Biosynthesis of collectodiol and related polyketide macrodiolides in Cytospora sp. ATTCC 20502: synthesis and metabolism of advanced intermediates
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 9,p. 738-740
- https://doi.org/10.1039/c39930000738
Abstract
The triene 3 and 6 have been syntesised in specifically labeled from and their incorporation into the macrodiolide, colletodio 1 demonstrated in cultures of Cytospora sp. ATCC 20502; results of a biomimetic reaction indicate that both colletoketol 2 and grahamimycin A17 may be biosynthesized in a single oxidation step from collectodiol.Keywords
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