γ-Glutamyltransferase Is a Helicobacter pylori Virulence Factor but Is Not Essential for Colonization
- 1 June 2001
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (6) , 4168-4173
- https://doi.org/10.1128/iai.69.6.4168-4173.2001
Abstract
The contribution of glutamyl transpeptidase (GGT) (γ-glutamyltransferase [EC 2. 3. 2. 2]) to Helicobacter pylori virulence was investigated in piglets and mice using GGT-deficient isogenic strains. All animals became colonized. However, the bacterial load was significantly lower for mutant bacteria than for parent strains. These results suggest that GGT activity provides an advantage to H. pylori in colonization.Keywords
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