Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.
Open Access
- 1 December 1982
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 79 (23) , 7425-7429
- https://doi.org/10.1073/pnas.79.23.7425
Abstract
The .kappa. L chain genes from 2 mutant hybridoma cell lines defective in .kappa. L chain synthesis were isolated and compared to the wild-type .kappa. L chain gene. The mutant .kappa. L chain genes were found to contain repetitive DNA elements in their intervening sequences that were not present in the intervening sequences of the wild-type .kappa. L chain gene. These elements were found to be related to the genes of intracisternal A particles. The decreased production of .kappa. L chain in the mutant cell lines is due to the presence of the intracisternal A particle-related genes.This publication has 46 references indexed in Scilit:
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