Reduced [3H]-tetrodotoxin binding in the nap ts paralytic mutant of Drosophila
- 1 September 1982
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 187 (1) , 172-173
- https://doi.org/10.1007/bf00384402
Abstract
The temperature-sensitive paralytic mutant of Drosophila, nap ts, has been shown to have defects in axonal physiology which suggest that it codes for a component of the voltage-sensitive sodium channel. Ligand binding studies using tritiated tetrodotoxin, a sodium channel antagonist, show a decrease in the apparent number of sodium channels in nap ts, providing additional support for this hypothesis.This publication has 11 references indexed in Scilit:
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