Faculty Opinions recommendation of Molecular and clinical diversity in paraneoplastic immunity to Ma proteins.

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Abstract
Paraneoplastic neurological disorders arise when an immune response against tumour antigens cross-reacts with proteins of the nervous system, and the neurological prognosis is usually very poor; however, the authors report a subtype of these conditions that seems to respond favourably to treatments. This study characterises the neurological disorders, associated tumours and response to treatment in 29 patients with antibodies to Ma1, Ma2 or Ma3, which are a family of recently-described proteins that may be involved in mRNA processing and are expressed predominantly in brain and testis. Remarkably, the presence of Ma2 antibodies exclusively was associated with an encouraging clinical response to immunosuppressive treatments in a proportion of patients.

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