Alkaloid Production in Catharanthus Roseus Cell Cultures. XI. Biotransformation of 3′, 4′‐Anhydrovinblastine to Other Bisindole Alkaloids
- 16 June 1982
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 65 (4) , 1271-1278
- https://doi.org/10.1002/hlca.19820650417
Abstract
Biotransformation studies of 3′,4′‐anhydrovinblastine (1) in Calharanthus roseus cell suspension cultures are reported. A detailed study of one cell line, coded at „916”︁, has revealed that 1 is transformed to the natural bisindole alkaloids leurosine (2) and Catharine (3) in approximately 25–30 and 9–16% yield, respectively. In 24–48 h, about 40% of 1 is utilized by the cells. Conditions for biotransformation of 1 have not been optimized so the above yields quoted are not final.Keywords
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