Computed tomography of the liver in rhesus monkeys following losefamate meglumine administration.

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Abstract
Iosefamate meglumine was evaluated for potential use as a contrast agent for hepatic computed tomography (CT) in rhesus monkeys. Iosefamate meglumine in doses of 150, 300 and 450 mg l/kg was injected into 4 rhesus monkeys and hepatic CT attenuation values, blood I levels, serum enzyme levels and hepatic histology were monitored. The hepatic CT number increased by 19-30 HU following a 150 mg l/kg dose and remained elevated for 15-45 min. Peak blood iodine values occurred 2 min postinjection but fell rapidly to < 40% of the peak value by 45 min and to < 20% of peak by 4 h. Transient elevations in serum enzyme levels were found but no histologic abnormalities were detected. Iosefamate meglumine is a potentially valuable hepatic C7 contrast agent, as it produces a significant, prolonged increase in hepatic attenuation values and selectively opacifies functioning hepatocytes.