The influence of intravenous glucose on blood-insulin activity in the rat

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Abstract
Isolated rat diaphragm was used to measure the insulin-like activity of plasma from rats given glucose intravenously. The activity is lower than normal for 30 minutes after the injection of glucose, and then rises above normal. The glucose uptake of diaphragm obtained from the glucose-injected rats was simultaneously examined by incubation in glucose-containing buffer. The glucose uptake first rises and then falls below normal. A possible interpretation of these results is that when the blood glucose rises insulin leaves the plasma and becomes bound to the tissues of the diaphragm, where it exerts a physiological effect.