Thyroxine Augmentation of Growth Hormone-Induced Endochondral Osteogenesis.
- 1 October 1966
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 123 (1) , 258-263
- https://doi.org/10.3181/00379727-123-31460
Abstract
Summary The possibility has been investigated that thyroxine is required to support the chondrogenetic effects of growth hormone in endochondral osteogenesis. Effects of these hormones have been determined in hypophy-sectomized, thyroidectomized, and hypophy-sectomized-thyroidectomized rats, being measured by the tibial epiphyseal plate widening response commonly employed in growth hormone assay. A dose of 1-thyroxine lying between 0.25 and 0.5 μg/day (a) restored vigorous endochondral osteogenesis in thyroidecto-mized rats, (b) increased their pituitary growth hormone content to normal, and (c) in hypophysectomized-thyroidectomized rats augmented the effect of a dose of growth hormone to equal that when the growth hormone dose was given alone to hypophysectomized rats.This publication has 14 references indexed in Scilit:
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