A New Type of Chemical Modification of Glycopeptides Antibiotics: Aminomethylated Derivatives of Eremomycin and Their Antibacterial Activity.
Open Access
- 1 January 1997
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 50 (6) , 509-513
- https://doi.org/10.7164/antibiotics.50.509
Abstract
A series of derivatives of eremomycin aminomethylated at the 7d position of the resorcinol ring of the amino acid No. 7 was prepared by interaction of eremomycin with formaldehyde and various primary and secondary amines and ammonia. The most active compound obtained was 7d-decylaminomethyl derivative, whose minimal inhibitory concentrations for clinical isolates of staphylococci are 2-8 times lower than those of the parent antibiotic. 7d-Decylaminomethyl derivative was also active against vancomycin-resistant VanA enterococci (8 μg/ml) and Neisseria gonorrhoeae (16 μg/ml).Keywords
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