Computational approach towards the three‐dimensional structure of E. coli tyrosine aminotransferase
- 20 July 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 306 (2-3) , 234-238
- https://doi.org/10.1016/0014-5793(92)81007-9
Abstract
We present a new model for E. coli tyrosine aminotransferase based on the X‐ray structures of the wild type and Val39Leu mutant of E. coli aspartate aminotransferase and computer simulation studies. Active site characteristics of the model are correlated with experimental observations on the specificity of these enzymes towards aromatic/dicarboxylic acid substrates.Keywords
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