EFFECT OF N-METHYL-N-BETA-CHLOROETHYLHYDRAZINE AND ITS BENZALDEHYDE HYDRAZONE ON RNA AND PROTEIN-SYNTHESIS AS SOON AS METABOLISM OF SYNCHRONOUSLY GROWING YEAST-CELLS (SACCHAROMYCES-CEREVISIAE)

  • 1 January 1976
    • journal article
    • research article
    • Vol. 31  (5-6) , 298-303
Abstract
N-methyl-N-.beta.-chloroethylhydrazine and its benzaldehydhydrazone inhibited the influx of [6-3H]-uracil and L-[U[universally labeled-14C]leucine in yeast cells as well as its incorporation in RNA and protein. Experiments with synchronously and asynchronously growing cells showed N-methyl-N-.beta.-chloroethylhydrazine primarily influences the dividing phase, while the benzaldehydehydrazone is more effective in the growth phase. The effect of these 2 substances on respiration, glycolysis and the concentration of fructose-1,6-diphosphate triose phosphate, and ATP is small.