Synthesis and biological properties of some novel heterocyclic homoprostanoids

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Abstract
In the search for prostaglandin-like structures capable of exerting specific and desirable biological properties, a variety of simple heterocyclic homoprostanoidal derivatives was synthesized from readily available stearic acid derivatives. Some compounds were more than 100 times as potent as PG[prostaglandin]E1 and PGE2 in a guinea pig tracheal chain bioassay and, inhibited PGE2-induced diarrhea. Some derivatives showed significant prostaglandin-synthetase inhibitor activity.