The Removal of Exogenous Triglycerides in Haemorrhagic Hyperlipidaemia in Rabbits

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Abstract
Bleedings (15 ml/day per kg body wt) on 2 consecutive days caused a 3-fold increase in plasma triglycerides (TG) in rabbits. In normal and in hemorrhagic rabbits the elimination of injected TG (fat emulsion) was exponential and the fractional removal rate in the hemorrhagic group was slower than normal. To rule out the possible effect of the TG pool in hemorrhagic rabbits and the possible changes in endogenous TG during the test, the TG were fractionated by the polyvinylpyrrolidone density gradient method. In normal and hemorrhagic rabbits the elimination of exogenous TG was exponential and the removal rate of hemorrhagic animals was retarded. The changes in endogenous TG were negligible. An elimination defect may be a factor in the pathogenesis of hemorrhagic hyperlipidemia.