A review of the literature concerning cerebral metastases from malignant tumors discloses that metastatic tumors to the brain from the parotid gland (mixed tumors) are extremly rare. A white woman of 41 had a mixed tumor of the parotid removed surgically. One year later she developed signs of increased intracranial pressure. Following investigation, a metastatic tumor similar to the parotid tumor was removed from the right frontal lobe. After a brief period of well being, the patient''s condition slowly deteriorated and she died about 10 weeks after the operation. Post-mortem examination showed no evidence of recurrent tumor of the parotid gland and no evidence of a recurrent tumor at the operative site in the right frontal area. However, there was a nodule in the left cerebellar hemisphere having the same histologic characteristics as the parotid tumor. The authors conclude that even in the face of metastic brain disease, an aggressive attitude should be taken except in patients with widespread metastases to the lungs, bones and lymph nodes. They also advise that in selective cases after the removal of 1 metastatic lesion, if symptoms recur, a search should be made for other metastatic lesions and, if only 1 or 2 such lesions are found, in some cases it might be worthwhile to perform multiple operations.